Rafael E. Alcalde, DDS, PhD
Dr. Alcalde is a Board Certified Surgeon and Diplomate of the American Board of Oral and Maxillofacial Surgery specialized in the treatment of patients with dentofacial deformities and facial reconstructive needs. He lectures and teaches courses at national and international level and has made numerous contributions to surgical textbooks and scientific journals.
After completing his dental education at the Universidad Central de Venezuela, Dr. Alcalde received his Oral and Maxillofacial Surgery training in Japan, The Netherlands and the US.
Upon completion of his residency, he joined the faculty and became full-time Attending Surgeon at the University of Washington, Seattle with an active clinical practice in different aspects of Surgical Orthodontics (Orthognathic Surgery and skeletal anchorage for orthodontics), Preprosthetic Surgery (Jaw reconstruction and dental implants) and Sleep Apnea Surgery. He participated in the teaching of Oral and Maxillofacial Surgery, Orthodontic and Prosthodontic Residents at University of Washington. After his extensive surgical training and academic career, he relocated his practice in South Florida where his main goal is to provide total quality care in the clinical & surgical management of Oral & Maxillofacial surgery patients needing surgical orthodontic, implant, facial reconstructive, and dentoalveolar procedures.
1985-1990: Dental School at Universidad Central de Venezuela
1992- 1997: Oral and Maxillofacial Surgery and PhD Okayama University, Japan
1997-1998: Orthognathic and Facial Reconstructive Surgery Fellowship Kagawa Central Hospital, Japan
1998-2002: Oral and Maxillofacial Surgery Residency Training University of Washington, Seattle
2001 Chief Resident, Rinjstate Hospital Arnhem, The Netherlands
American Board of Oral and Maxillofacial Surgery
American Dental Society of Anesthesiology
Reviewer “American Journal of Oral and Maxillofacial Surgery”
South Miami Hospital
PUBLICATIONS AND PRESENTATIONS
Lopez-Nardorfi E, Alcalde RE. Asociacion Venezolana para el Avance de la Ciencia. 1991 (Spanish)
Alcalde RE, Ueyama Y, Nishiyama A, Mizuguchi T, Matsumura T, Kishi K. Diagnostic imaging of Eagle’s syndrome. Oral Radiol. 1994;10:143-8.
Alcalde RE, Mizuguchi T, Tada K, Ueyama Y, Matsumura T, Kishi K. Comparison of accuracy of different imaging techniques in the assessment of distances for evaluation of the anatomical structures. Proceedings IADMFR. 1994;199-201.
Kishi K, Hirakawa K, Alcalde RE, Akaki S, Hiraki Y, Ueyama Y, Matsumura T. Three-dimensional plastic modeling system using CT images as an aid to operative planning. Proceedings IADMFR.1994; 152-5.
Shintani S, Yoshihama Y, Alcalde RE, Matsumura T. Overexpression of p53 is an early event in the tumorigenesis of oral squamous cell carcinomas. Anticancer Res.1995;15:305-8.
Alcalde RE, Shintani S, Yoshihama Y, Matsumura T. Cell proliferation and tumor angiogenesis in oral squamous cell carcinoma. Anticancer Res. 1995;15:1417-22.
Shintani S, Funayama T, Yoshihama Y, Alcalde RE, Matsumura T. Prognostic significance of ERRB3 overexpression in oral squamous cell carcinoma. Cancer Letters. 1995;95:79-83.
Alcalde RE, Sasaki A, Misaki M, Matsumura T. Odontogenic ghost cell carcinoma: Report of a case and review of the literature. J Oral Maxillofac Surg. 1996;54:108-11.
Shintani S, Funayama T, Yoshihama Y, Alcalde RE, Otsuki K, Terakado N, Matsumura T. Expression of C-erbB family gene products in adenoid cystic carcinoma of salivary glands: An immunohistochemical study. Anticancer Res.1995;15:2623-6.
Ohyama K, Yoshihama Y, Alcalde RE, Matsumura T. Expression of p53 and MDM2 in Oral Squamous cell carcinoma. Oral Oncology.1995;Vol IVb:71-72.
Alcalde RE, Shintani S, Yoshihama Y, Matsumura T. Angiogenesis and cell proliferation in oral squamous cell carcinoma. Oral Oncology.1995;Vol IVb:336-339.
Otsuki K, Alcalde RE, Matsumura T, Kimura N. Immunohistochemical analysis of NDP (nucleoside diphosphate) kinase in oral squamous cell carcinoma. Oral Oncology.1995;Vol IVb:107-110.
Shintani S, Matsumura T, Alcalde RE, Yoshihama Y. Sequential expression of myc-, ras-, oncogene products and EGF receptor during DMBA-induced tongue carcinogenesis. Int J Oncology. 1996;8:821-826.
Shintani S, Terakado N, Alcalde RE, Tomisawa K, Kobayashi T, Yamada Y, Kishimoto K, Mano T, Matsumura T. Retrospective study of unsuccessful dental implants (in Japanese). J Okayama Dent Assoc. 1996
Matsumura T, Yoshihama Y, Shintani S, Kimura T, Alcalde RE. p53 and MDM2 expression in oral squamous cell carcinoma. Oncology. 1996;53:308-312.
Otsuki K, Alcalde RE, Matsumura T, Kimura N. Immunohistochemical analysis of NDP (nucleoside diphosphate) kinase in oral squamous cell carcinoma. Oncology. 1997;54:63-68.
Alcalde RE, Terakado N, Otsuki K, Matsumura T. Angiogenesis and expression of platelet-derived endothelial cell growth factor in oral squamous cell carcinoma. Oncology.1997;54:324-28
Shintani S, Alcalde RE, Matsumura T, Terakado N. Extracellular matrices expression in invasion area of adenoid cystic carcinoma of salivary glands. Cancer Letters. Cancer Letters 1997;116:9-14
Alcalde RE, Jinno T, Pogrel MA, Matsumura T. Cephalometric norms for orthognathic surgery in Japanese adults. J Oral Maxillofac Surg. 1998;56:129-34.
Sasaki A, Yoneda T, Terakado N, Alcalde RE, Suzuki A, Matsumura T. Bone metastasis model of the oral region. Anticancer Res. 1998;18:1579-84.
Alcalde RE, Ueyama Y, Lim DD, Matsumura T. Pneumoparotitits: Report of a case and review of the literature. J Oral Maxillofac Surg. 1998;56:676-80.
Sasaki A, Nishiyama A, Alcalde RE, Lim DD, Mese H, Nakayama S, Yokoyama S, Matsumura T. Effects of bisphosphonates on experimental jaw metastasis model in nude mice. Oral oncology 1999;35:523-529
Sasaki A, Kitamura K, Alcalde RE, Tanaka T, Suzuki A, Etoh Y, Matsumura T. Effect of a newly developed biphosphonate, YH529, on osteolytic bone metastases in nude mice. Int J Cancer.1998;77:279-285.
Sasaki A, Alcalde RE, Nishiyama A, Lim DD, Mese H, Matsumura T. Angiogenesis inhibitor TNP-470 inhibits human breast cancer osteolytic bone metastasis in nude mice through the reduction of bone resorption. Cancer Res. 1998;58:462-67.
Shintani S, Terakado N, Alcalde RE, Tomizawa K, Nakayama S, Ueyama Y, Ichikawa H, Sugimoto T, Matsumura T. An anatomical study of the arteries for intraarterial chemotherapy of head and neck cancer. Int J Clin Oncol. 1999;4:327-330
Shintani S, Terakado N, Alcalde RE, Tomizawa K, Mihara M, Nakahara Y, Kiyota A, Yoshihama Y, Matsumura T. The influence of blood arterial oxygen condition on the tumor response to preoperative radiation therapy in oral cancer patients. Oncol Reports. 2001;8:99-102.
Iwata M, Takebayashi T, Ohta H, Alcalde RE, Itano Y, Matsumura T. Zinc accumulation and metallothionein gene expression in the proliferating epidermis during wound healing in mouse skin. Histochem Cell Biol. 1999;112:283-290
Mese H, Sasaki A, Alcalde RE, Nakayama S, Matsumura T. Establishment and characterization of cisplatin-resistant human epidermoid carcinoma cell line, A431 cell. Chemotherapy. Chemotherapy1998;44:414-420
Mese H, Sasaki A, Alcalde RE, Nakayama S, Matsumura T. Regulation of apoptosis reduction in cisplatin-resistant A431 cell line by Bcl-2 and CPP32. Chemotherapy 2000;46:69-76
Nakayama S, Sasaki A, Mese H, Alcalde RE, Matsumura T. Establishment of high and low metastasis cell lines derived from a human tongue squamous cell carcinoma. Invasion Metastasis 1998/99;18:219-228
Mese H, Sasaki A, Nakayama S, Alcalde RE, Matsumura T. The role of caspase family protease, caspase-3 on cisplatin-induced apoptosis in cisplatin-resistant A431 cell line. Cancer Chemother Pharmacol 2000;46:241-245
Sasaki A, Alcalde RE, Tsukamoto G, Mese H, Nagatsuka H, Yoshioka N, Matsumura T. Florid cemento-osseous dysplasia with concomitant simple bone cyst. Report of a case. Asian J Oral Maxillofac Surg 2000;12:225-229
Alcalde R.E, Jinno T, Orsini M.G, Sasaki A, Sugiyama R, Matsumura T. Soft tissue cephalometric norms in Japanese adults. Am J Orthod Dentofacial Orthop 2000; 118: 84-9.
Nakayama S, Sasaki A, Mese H, Alcalde RE, Tsuji T, Matsumura T.
The E-cadherin gene is silenced by CpG methylation in human oral squamous cell carcinomas. Int J Cancer 2001; 93: 667-73.
Collins C, Pirinjian G, Tolas A, Alcalde RE. A Prospective Randomized Clinical Trial Comparing 2.0-mm Locking Plates to 2.0 mm Standard Plates in Treatment of Mandible Fractures. J Oral Maxillofac Surg 2004;11: 1392-1395.
Mitsugi M, Ito O, Alcalde RE. Maxillary bone transportation in alveolar cleft-transport distraction osteogenesis for treatment of alveolar cleft repair. British J Plastic Surgery 2005; 58, 619-625.